The signal response of IkappaB alpha is regulated by transferable N- and C-terminal domains.

IkappaB alpha retains the transcription factor NF-kappaB in the cytoplasm, thus inhibiting its function. Various stimuli inactivate IkappaB alpha by triggering phosphorylation of the N-terminal residues Ser32 and Ser36. Phosphorylation of both serines is demonstrated directly by phosphopeptide mappi...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Brown, K, Franzoso, G, Baldi, L, Carlson, L, Mills, L, Lin, Y C, Gerstberger, S, Siebenlist, U
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232154/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9154800/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.6.3021
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