The signal response of IkappaB alpha is regulated by transferable N- and C-terminal domains.

IkappaB alpha retains the transcription factor NF-kappaB in the cytoplasm, thus inhibiting its function. Various stimuli inactivate IkappaB alpha by triggering phosphorylation of the N-terminal residues Ser32 and Ser36. Phosphorylation of both serines is demonstrated directly by phosphopeptide mappi...

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Main Authors: Brown, K, Franzoso, G, Baldi, L, Carlson, L, Mills, L, Lin, Y C, Gerstberger, S, Siebenlist, U
Format: Artigo
Jezik:Inglês
Izdano: 1997
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC232154/
https://ncbi.nlm.nih.gov/pubmed/9154800
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