The signal response of IkappaB alpha is regulated by transferable N- and C-terminal domains.
IkappaB alpha retains the transcription factor NF-kappaB in the cytoplasm, thus inhibiting its function. Various stimuli inactivate IkappaB alpha by triggering phosphorylation of the N-terminal residues Ser32 and Ser36. Phosphorylation of both serines is demonstrated directly by phosphopeptide mappi...
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| Veröffentlicht in: | Mol Cell Biol |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Taylor & Francis
1997
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232154/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9154800/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.6.3021 |
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