IkappaBalpha deficiency results in a sustained NF-kappaB response and severe widespread dermatitis in mice.

The ubiquitous transcription factor NF-kappaB is an essential component in signal transduction pathways, in inflammation, and in the immune response. NF-kappaB is maintained in an inactive state in the cytoplasm by protein-protein interaction with IkappaBalpha. Upon stimulation, rapid degradation of...

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Hlavní autoři: Klement, J F, Rice, N R, Car, B D, Abbondanzo, S J, Powers, G D, Bhatt, P H, Chen, C H, Rosen, C A, Stewart, C L
Médium: Artigo
Jazyk:Inglês
Vydáno: 1996
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC231222/
https://ncbi.nlm.nih.gov/pubmed/8628301
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