IkappaBalpha deficiency results in a sustained NF-kappaB response and severe widespread dermatitis in mice.
The ubiquitous transcription factor NF-kappaB is an essential component in signal transduction pathways, in inflammation, and in the immune response. NF-kappaB is maintained in an inactive state in the cytoplasm by protein-protein interaction with IkappaBalpha. Upon stimulation, rapid degradation of...
Uloženo v:
| Vydáno v: | Mol Cell Biol |
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| Hlavní autoři: | , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Taylor & Francis
1996
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231222/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8628301/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.5.2341 |
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