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IkappaBalpha deficiency results in a sustained NF-kappaB response and severe widespread dermatitis in mice.

The ubiquitous transcription factor NF-kappaB is an essential component in signal transduction pathways, in inflammation, and in the immune response. NF-kappaB is maintained in an inactive state in the cytoplasm by protein-protein interaction with IkappaBalpha. Upon stimulation, rapid degradation of...

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Udgivet i:Mol Cell Biol
Principais autores: Klement, J F, Rice, N R, Car, B D, Abbondanzo, S J, Powers, G D, Bhatt, P H, Chen, C H, Rosen, C A, Stewart, C L
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231222/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8628301/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.5.2341
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