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The Drosophila insulin receptor activates multiple signaling pathways but requires insulin receptor substrate proteins for DNA synthesis.

The Drosophila insulin receptor (DIR) contains a 368-amino-acid COOH-terminal extension that contains several tyrosine phosphorylation sites in YXXM motifs. This extension is absent from the human insulin receptor but resembles a region in insulin receptor substrate (IRS) proteins which binds to the...

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Published in:Mol Cell Biol
Main Authors: Yenush, L, Fernandez, R, Myers, M G, Grammer, T C, Sun, X J, Blenis, J, Pierce, J H, Schlessinger, J, White, M F
Format: Artigo
Language:Inglês
Published: Taylor & Francis 1996
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231240/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8628319/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.5.2509
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