mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein.

The mdm-2 gene encodes a 90-kDa polypeptide that binds specifically to the p53 tumor suppressor protein. This physical interaction results in the inhibition of the transcriptional functions of p53 (J. Chen, J. Lin, and A. J. Levine, Mol. Med. 1:142-152, 1995, and J. Momand, G. P. Zambetti, D. C. Ols...

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Dades bibliogràfiques

Publicat a:	Mol Cell Biol
Autors principals:	Chen, J, Wu, X, Lin, J, Levine, A J
Format:	Artigo
Idioma:	Inglês
Publicat:	Taylor & Francis 1996
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231233/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8628312/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.5.2445
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