mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein.

The mdm-2 gene encodes a 90-kDa polypeptide that binds specifically to the p53 tumor suppressor protein. This physical interaction results in the inhibition of the transcriptional functions of p53 (J. Chen, J. Lin, and A. J. Levine, Mol. Med. 1:142-152, 1995, and J. Momand, G. P. Zambetti, D. C. Ols...

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Detalles Bibliográficos

Publicado en:	Mol Cell Biol
Principais autores:	Chen, J, Wu, X, Lin, J, Levine, A J
Formato:	Artigo
Idioma:	Inglês
Publicado:	Taylor & Francis 1996
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231233/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8628312/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.5.2445
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