Constitutive expression of B-myb can bypass p53-induced Waf1/Cip1-mediated G1 arrest.

Overexpression of wild-type p53 protein has been shown to induce arrest in the G1 stage of the cell cycle and to transactivate expression of the gene that encodes the 21-kDa Waf1/Cip1 protein, a potent inhibitor of cyclin-dependent kinase activity. p53-dependent G1 arrest is accompanied by decreased...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Lin, D, Fiscella, M, O'Connor, P M, Jackman, J, Chen, M, Luo, L L, Sala, A, Travali, S, Appella, E, Mercer, W E
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1994
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44961/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7937841/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.21.10079
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