mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein.
The mdm-2 gene encodes a 90-kDa polypeptide that binds specifically to the p53 tumor suppressor protein. This physical interaction results in the inhibition of the transcriptional functions of p53 (J. Chen, J. Lin, and A. J. Levine, Mol. Med. 1:142-152, 1995, and J. Momand, G. P. Zambetti, D. C. Ols...
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| Pubblicato in: | Mol Cell Biol |
|---|---|
| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Taylor & Francis
1996
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231233/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8628312/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.5.2445 |
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