p53 and E2F-1 cooperate to mediate apoptosis.
The tumor-suppressor protein p53 appears to function at the G1 phase of the cell cycle as a checkpoint in response to DNA damage. Mutations in the p53 gene lead to an increased rate of genomic instability and tumorigenesis. The E2F-1 transcription factor is a protein partner of the retinoblastoma-su...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1994
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43628/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8170954/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.9.3602 |
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