Coexpression of factor VIII heavy and light chain adeno-associated viral vectors produces biologically active protein

We are interested in using recombinant adeno-associated viral vectors in the treatment of hemophilia A. Because of the size constraints of recombinant adeno-associated viral vectors, we delivered the heavy and light chains of the human factor 8 (hFVIII) cDNA independently by using two separate vecto...

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I whakaputaina i:	Proc Natl Acad Sci U S A
Ngā kaituhi matua:	Burton, Melissa, Nakai, Hiroyuki, Colosi, Peter, Cunningham, Janet, Mitchell, Rachel, Couto, Linda
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	National Academy of Sciences 1999
Ngā marau:	Biological Sciences
Urunga tuihono:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23069/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10535990/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.22.12725
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Coexpression of factor VIII heavy and light chain adeno-associated viral vectors produces biologically active protein

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