A Limited Number of Transducible Hepatocytes Restricts a Wide-Range Linear Vector Dose Response in Recombinant Adeno-Associated Virus-Mediated Liver Transduction

Recombinant adeno-associated virus (rAAV) vectors are promising vehicles for achieving stable liver transduction in vivo. However, the mechanisms of liver transduction are not fully understood, and furthermore, the relationships between rAAV dose and levels of transgene expression, total number of h...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Nakai, Hiroyuki, Thomas, Clare E., Storm, Theresa A., Fuess, Sally, Powell, Sharon, Wright, J. Fraser, Kay, Mark A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2002
Assuntos:	Gene Therapy
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136786/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12388694/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.22.11343-11349.2002
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