A Limited Number of Transducible Hepatocytes Restricts a Wide-Range Linear Vector Dose Response in Recombinant Adeno-Associated Virus-Mediated Liver Transduction

Recombinant adeno-associated virus (rAAV) vectors are promising vehicles for achieving stable liver transduction in vivo. However, the mechanisms of liver transduction are not fully understood, and furthermore, the relationships between rAAV dose and levels of transgene expression, total number of h...

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Main Authors: Nakai, Hiroyuki, Thomas, Clare E., Storm, Theresa A., Fuess, Sally, Powell, Sharon, Wright, J. Fraser, Kay, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2002
Assuntos:
Gene Therapy
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC136786/
https://ncbi.nlm.nih.gov/pubmed/12388694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.22.11343-11349.2002
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