A Limited Number of Transducible Hepatocytes Restricts a Wide-Range Linear Vector Dose Response in Recombinant Adeno-Associated Virus-Mediated Liver Transduction

Recombinant adeno-associated virus (rAAV) vectors are promising vehicles for achieving stable liver transduction in vivo. However, the mechanisms of liver transduction are not fully understood, and furthermore, the relationships between rAAV dose and levels of transgene expression, total number of h...

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Bibliografische Detailangaben

Veröffentlicht in:	J Virol
Hauptverfasser:	Nakai, Hiroyuki, Thomas, Clare E., Storm, Theresa A., Fuess, Sally, Powell, Sharon, Wright, J. Fraser, Kay, Mark A.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2002
Schlagworte:	Gene Therapy
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136786/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12388694/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.22.11343-11349.2002
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