Extrachromosomal Recombinant Adeno-Associated Virus Vector Genomes Are Primarily Responsible for Stable Liver Transduction In Vivo

Recombinant adeno-associated virus (rAAV) vectors stably transduce hepatocytes in experimental animals. Although the vector genomes are found both as extrachromosomes and as chromosomally integrated forms in hepatocytes, the relative proportion of each has not yet been clearly established. Using an...

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Detalhes bibliográficos
Main Authors: Nakai, Hiroyuki, Yant, Stephen R., Storm, Theresa A., Fuess, Sally, Meuse, Leonard, Kay, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC114425/
https://ncbi.nlm.nih.gov/pubmed/11435577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.15.6969-6976.2001
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