Nonrandom Transduction of Recombinant Adeno-Associated Virus Vectors in Mouse Hepatocytes In Vivo: Cell Cycling Does Not Influence Hepatocyte Transduction

Recombinant adeno-associated virus vectors (rAAV) show promise in preclinical trials for the treatment of genetic diseases including hemophilia. Liver-directed gene transfer results in a slow rise in transgene expression, reaching steady-state levels over a period of 5 weeks concomitant with the con...

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Bibliographic Details
Main Authors: Miao, Carol H., Nakai, Hiroyuki, Thompson, Arthur R., Storm, Theresa A., Chiu, Winnie, Snyder, Richard O., Kay, Mark A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2000
Subjects:
Gene Therapy
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC111888/
https://ncbi.nlm.nih.gov/pubmed/10729154
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