Binding of ZAP-70 to phosphorylated T-cell receptor zeta and eta enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins.

Ítems similars

• ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity
  Publicat: (1995)
• Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker
  per: Yan, Qingrong, et al.
  Publicat: (2013)
• The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling
  per: Cheng, Alec M., et al.
  Publicat: (1997)
• Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT
  per: Lo, Wan-Lin, et al.
  Publicat: (2018)
• The T-cell receptor zeta chain contains a GTP/GDP binding site.
  per: Peter, M E, et al.
  Publicat: (1992)