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ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity

Engagement of the T cell antigen receptor (TCR) results in activation of several tyrosine kinases leading to tyrosine phosphorylation of protein substrates and activation of multiple biochemical pathways. TCR- mediated activation of the src-family kinases, Lck and Fyn, results in tyrosine phosphoryl...

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Podrobná bibliografie
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 1995
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2191847/
https://ncbi.nlm.nih.gov/pubmed/7528772
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