PAK4 Kinase Is Essential for Embryonic Viability and for Proper Neuronal Development

The serine/threonine kinase PAK4 is a target for the Rho GTPase Cdc42 and has been shown to regulate cell morphology and cytoskeletal organization in mammalian cells. To examine the physiological and developmental functions of PAK4, we have disrupted the PAK4 gene in mice. The absence of PAK4 led to...

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Bibliographische Detailangaben
Hauptverfasser: Qu, Jian, Li, Xiaofan, Novitch, Bennet G., Zheng, Ye, Kohn, Matthew, Xie, Jian-Ming, Kozinn, Spencer, Bronson, Roderick, Beg, Amer A., Minden, Audrey
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2003
Schlagworte:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC230313/
https://ncbi.nlm.nih.gov/pubmed/14517283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.20.7122-7133.2003
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