Targeted Disruption of the Methionine Synthase Gene in Mice

Alterations in homocysteine, methionine, folate, and/or B(12) homeostasis have been associated with neural tube defects, cardiovascular disease, and cancer. Methionine synthase, one of only two mammalian enzymes known to require vitamin B(12) as a cofactor, lies at the intersection of these metaboli...

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Main Authors: Swanson, Deborah A., Liu, Mei-Lan, Baker, Priscilla J., Garrett, Lisa, Stitzel, Michael, Wu, Jianmin, Harris, Michelle, Banerjee, Ruma, Shane, Barry, Brody, Lawrence C.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2001
Teme:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC99560/
https://ncbi.nlm.nih.gov/pubmed/11158293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.4.1058-1065.2001
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