Targeted Disruption of the Methionine Synthase Gene in Mice

Alterations in homocysteine, methionine, folate, and/or B(12) homeostasis have been associated with neural tube defects, cardiovascular disease, and cancer. Methionine synthase, one of only two mammalian enzymes known to require vitamin B(12) as a cofactor, lies at the intersection of these metaboli...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Swanson, Deborah A., Liu, Mei-Lan, Baker, Priscilla J., Garrett, Lisa, Stitzel, Michael, Wu, Jianmin, Harris, Michelle, Banerjee, Ruma, Shane, Barry, Brody, Lawrence C.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 2001
Schlagworte:	Mammalian Genetic Models with Minimal or Complex Phenotypes
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC99560/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11158293/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.4.1058-1065.2001
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Targeted Disruption of the Methionine Synthase Gene in Mice

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