Targeted Disruption of the Inosine 5′-Monophosphate Dehydrogenase Type I Gene in Mice

Inosine 5′-monophosphate dehydrogenase (IMPDH) is the critical, rate-limiting enzyme in the de novo biosynthesis pathway for guanine nucleotides. Two separate isoenzymes, designated IMPDH types I and II, contribute to IMPDH activity. An additional pathway salvages guanine through the activity of hyp...

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Autors principals: Gu, Jing Jin, Tolin, Amy K., Jain, Jugnu, Huang, Hai, Santiago, Lalaine, Mitchell, Beverly S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2003
Matèries:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC193693/
https://ncbi.nlm.nih.gov/pubmed/12944494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.18.6702-6712.2003
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