Targeted Disruption of the Inosine 5′-Monophosphate Dehydrogenase Type I Gene in Mice

Inosine 5′-monophosphate dehydrogenase (IMPDH) is the critical, rate-limiting enzyme in the de novo biosynthesis pathway for guanine nucleotides. Two separate isoenzymes, designated IMPDH types I and II, contribute to IMPDH activity. An additional pathway salvages guanine through the activity of hyp...

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Bibliographic Details

Published in:	Mol Cell Biol
Main Authors:	Gu, Jing Jin, Tolin, Amy K., Jain, Jugnu, Huang, Hai, Santiago, Lalaine, Mitchell, Beverly S.
Format:	Artigo
Language:	Inglês
Published:	Taylor & Francis 2003
Subjects:	Mammalian Genetic Models with Minimal or Complex Phenotypes
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC193693/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12944494/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.18.6702-6712.2003
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