Phosphorylation of IRF-3 on Ser 339 Generates a Hyperactive Form of IRF-3 through Regulation of Dimerization and CBP Association

The IκB kinase-related kinases, TBK1 and IKKi, were recently shown to be responsible for the C-terminal phosphorylation of IRF-3. However, the identity of the phosphoacceptor site(s) targeted by these two kinases remains unclear. Using a biological assay based on the IRF-3-mediated production of ant...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Clément, Jean-François, Bibeau-Poirier, Annie, Gravel, Simon-Pierre, Grandvaux, Nathalie, Bonneil, Éric, Thibault, Pierre, Meloche, Sylvain, Servant, Marc J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology (ASM) 2008
Ämnen:
Virus-Cell Interactions
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292984/
https://ncbi.nlm.nih.gov/pubmed/18272581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02526-07
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk