N-Terminal Ubiquitination of Extracellular Signal-Regulated Kinase 3 and p21 Directs Their Degradation by the Proteasome

Extracellular signal-regulated kinase 3 (ERK3) is an unstable mitogen-activated protein kinase homologue that is constitutively degraded by the ubiquitin-proteasome pathway in proliferating cells. Here we show that a lysineless mutant of ERK3 is still ubiquitinated in vivo and requires a functional...

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Détails bibliographiques
Publié dans:Mol Cell Biol
Auteurs principaux: Coulombe, Philippe, Rodier, Geneviève, Bonneil, Eric, Thibault, Pierre, Meloche, Sylvain
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2004
Sujets:
Cell Growth and Development
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC434260/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15226418/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.14.6140-6150.2004
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