Rapid Turnover of Extracellular Signal-Regulated Kinase 3 by the Ubiquitin-Proteasome Pathway Defines a Novel Paradigm of Mitogen-Activated Protein Kinase Regulation during Cellular Differentiation

Mitogen-activated protein (MAP) kinases are stable enzymes that are mainly regulated by phosphorylation and subcellular targeting. Here we report that extracellular signal-regulated kinase 3 (ERK3), unlike other MAP kinases, is an unstable protein that is constitutively degraded in proliferating cel...

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Main Authors: Coulombe, Philippe, Rodier, Geneviève, Pelletier, Stéphane, Pellerin, Johanne, Meloche, Sylvain
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2003
Assuntos:
Cell Growth and Development
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC164847/
https://ncbi.nlm.nih.gov/pubmed/12808096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.13.4542-4558.2003
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