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S-glutathionylation of IRF3 regulates IRF3–CBP interaction and activation of the IFNβ pathway
Interferon regulatory factor 3 (IRF3) is an essential transcriptional regulator of the interferon genes. IRF3 is constitutively present in a latent conformation in the cell cytoplasm. In cells infected by Sendai virus, IRF3 becomes phosphorylated, homodimerizes, translocates to the nucleus, binds to...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2274937/ https://ncbi.nlm.nih.gov/pubmed/18309294 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.28 |
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