Rebamipide suppresses TLR-TBK1 signaling pathway resulting in regulating IRF3/7 and IFN-α/β reduction

TANK-binding kinase 1 (TBK1) regulates the interferon regulatory factor (IRF) 3 and IRF7 activation pathways by double strand RNA (dsRNA) via Toll-like receptor (TLR) 3 and by lipopolysaccharide (LPS) via TLR4. Rebamipide is useful for treating inflammatory bowel disease (IBD). Although IBD is assoc...

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Bibliographic Details
Main Authors: Ogasawara, Naotaka, Sasaki, Makoto, Itoh, Yukimi, Tokudome, Kentaro, Kondo, Yoshihiro, Ito, Yoshitsugi, Tanida, Satoshi, Kamiya, Takeshi, Kataoka, Hiromi, Joh, Takashi, Kasugai, Kunio
Format: Artigo
Language:Inglês
Published: the Society for Free Radical Research Japan 2011
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045689/
https://ncbi.nlm.nih.gov/pubmed/21373269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3164/jcbn.10-69
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