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Safety, Tolerance, and Pharmacokinetic Studies of OPT-80 in Healthy Volunteers following Single and Multiple Oral Doses

Current therapies for Clostridium difficile infection (CDI) are encumbered by treatment failures and recurrences. Due to its high in vitro activity against C. difficile but low activity against the typical intestinal flora, minimal absorption, and durable cure in the hamster model of C. difficile in...

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Main Authors: Shue, Y. K., Sears, P. S., Shangle, S., Walsh, R. B., Lee, C., Gorbach, S. L., Okumu, F., Preston, R. A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292557/
https://ncbi.nlm.nih.gov/pubmed/18268081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01045-07
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