Ibudilast in healthy volunteers: safety, tolerability and pharmacokinetics with single and multiple doses

AIMS: To investigate the safety, tolerability and pharmacokinetics (PK) of ibudilast after a single-dose and a multiple-dose regimen. METHODS: Healthy adult male (n = 9) and female (n = 9) volunteers were evaluated over a 17-day stay in a Phase 1 unit. Subjects were randomized 1 : 3 to either oral p...

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Bibliografiske detaljer
Main Authors: Rolan, Paul, Gibbons, Jacqueline A, He, Lin, Chang, Eppie, Jones, Drew, Gross, Matthew I, Davidson, Jennifer Bahr, Sanftner, Laura M, Johnson, Kirk W
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2008
Fag:
Pharmacokinetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2675769/
https://ncbi.nlm.nih.gov/pubmed/19032723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2008.03270.x
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