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Safety, tolerability and pharmacokinetics of higher-dose mizoribine in healthy male volunteers

AIMS: Mizoribine is an oral immunosuppressive agent approved in several countries for prevention of rejection in renal transplantation. Its therapeutic window is based on trough concentrations staying at ≥0.5 but <3 µg ml(−1). It has been postulated that as renal function returns to normal, highe...

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Detalhes bibliográficos
Main Authors: Stypinski, Daria, Obaidi, Mohammad, Combs, Michelle, Weber, Meg, Stewart, Adrian J, Ishikawa, Hiroaki
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2203250/
https://ncbi.nlm.nih.gov/pubmed/17096684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2006.02779.x
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