Pharmacokinetics and tolerability of artesunate and amodiaquine alone and in combination in healthy volunteers

OBJECTIVES: The WHO recommends artemisinin-based combination therapies for treatment of uncomplicated falciparum malaria. At least 15 African countries have adopted artesunate plus amodiaquine as treatment policy. As no pharmacokinetic data on this combination have been published to date, we investi...

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Bibliographic Details
Main Authors: Orrell, Catherine, Little, Francesca, Smith, Peter, Folb, Peter, Taylor, Walter, Olliaro, Piero, Barnes, Karen I.
Format: Artigo
Language:Inglês
Published: Springer-Verlag 2008
Subjects:
Pharmacokinetics and Disposition
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2426925/
https://ncbi.nlm.nih.gov/pubmed/18415093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-007-0452-8
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