Pharmacokinetics and Ex Vivo Antimalarial Activity of Artesunate-Amodiaquine plus Methylene Blue in Healthy Volunteers

High rates of artemisinin-based combination therapy (ACT) failures in the treatment of Plasmodium falciparum malaria in Southeast Asia have led to triple-drug strategies to extend the useful life of ACTs. In this study, we determined whether methylene blue [MB; 3,7-bis(dimethylamino)phenothiazin-5-i...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Antimicrob Agents Chemother
Prif Awduron: Anh, Chu Xuan, Chavchich, Marina, Birrell, Geoffrey W., Van Breda, Karin, Travers, Thomas, Rowcliffe, Kerryn, Lord, Anton R., Shanks, G. Dennis, Edstein, Michael D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2020
Pynciau:
Pharmacology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7038242/
https://ncbi.nlm.nih.gov/pubmed/31907186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01441-19
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