Tolerability and pharmacokinetics of non-fixed and fixed combinations of artesunate and amodiaquine in Malaysian healthy normal volunteers

OBJECTIVE: There is limited pharmacokinetic data available for the combination artesunate + amodiaquine, which is used widely to treat uncomplicated malaria. This study examines the bioavailability and tolerability of a fixed (200 mg artesunate + 540 mg amodiaquine) and loose (200 mg + 612 mg) combi...

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Detalhes bibliográficos
Main Authors: Navaratnam, Visweswaran, Ramanathan, Surash, Wahab, Mohd Suhaimi Ab., Siew Hua, Gan, Mansor, Sharif Mahsufi, Kiechel, Jean-René, Vaillant, Michel, Taylor, Walter R. J., Olliaro, Piero
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2009
Assuntos:
Pharmacokinetics and Disposition
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714898/
https://ncbi.nlm.nih.gov/pubmed/19404632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-009-0656-1
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