Relationship between Antimalarial Activity and Heme Alkylation for Spiro- and Dispiro-1,2,4-Trioxolane Antimalarials

The reaction of spiro- and dispiro-1,2,4-trioxolane antimalarials with heme has been investigated to provide further insight into the mechanism of action for this important class of antimalarials. A series of trioxolanes with various antimalarial potencies was found to be unreactive in the presence...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Creek, Darren J., Charman, William N., Chiu, Francis C. K., Prankerd, Richard J., Dong, Yuxiang, Vennerstrom, Jonathan L., Charman, Susan A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology (ASM) 2008
Gaiak:
Mechanisms of Action: Physiological Effects
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292547/
https://ncbi.nlm.nih.gov/pubmed/18268087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01033-07
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