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Investigating the Antimalarial Action of 1,2,4-Trioxolanes with Fluorescent Chemical Probes
The 1,2,4-trioxolanes are a new class of synthetic peroxidic antimalarials currently in human clinical trials. The well known reactivity of the 1,2,4-trioxolane ring towards inorganic ferrous iron and ferrous iron heme is proposed to play a role in the antimalarial action of this class of compounds....
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3236788/ https://ncbi.nlm.nih.gov/pubmed/22023506 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm2012003 |
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