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Mechanism of Antimalarial Action of the Synthetic Trioxolane RBX11160 (OZ277)

RBX11160 (OZ277) is a fully synthetic peroxidic antimalarial in clinical development. To study the possible mechanisms of action of RBX11160, we have examined its ability to inhibit PfATP6, a sarcoplasmic reticulum calcium ATPase and proposed target for semisynthetic peroxidic artemisinin derivative...

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Bibliografski detalji
Glavni autori: Uhlemann, Anne-Catrin, Wittlin, Sergio, Matile, Hugues, Bustamante, Leyla Y., Krishna, Sanjeev
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2007
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1797759/
https://ncbi.nlm.nih.gov/pubmed/17145800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01064-06
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