Peroxide Bond-Dependent Antiplasmodial Specificity of Artemisinin and OZ277 (RBx11160)

Using nonperoxidic analogs of artemisinin and OZ277 (RBx11160), the strong in vitro antiplasmodial activities of the latter two compounds were shown to be peroxide bond dependent. In contrast, the weak activities of artemisinin and OZ277 against six other protozoan parasites were peroxide bond indep...

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Detalhes bibliográficos
Main Authors: Kaiser, Marcel, Wittlin, Sergio, Nehrbass-Stuedli, Angela, Dong, Yuxiang, Wang, Xiaofang, Hemphill, Andrew, Matile, Hugues, Brun, Reto, Vennerstrom, Jonathan L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1932508/
https://ncbi.nlm.nih.gov/pubmed/17562801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00225-07
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