Peroxide Bond-Dependent Antiplasmodial Specificity of Artemisinin and OZ277 (RBx11160)

Using nonperoxidic analogs of artemisinin and OZ277 (RBx11160), the strong in vitro antiplasmodial activities of the latter two compounds were shown to be peroxide bond dependent. In contrast, the weak activities of artemisinin and OZ277 against six other protozoan parasites were peroxide bond indep...

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Bibliografiske detaljer
Main Authors: Kaiser, Marcel, Wittlin, Sergio, Nehrbass-Stuedli, Angela, Dong, Yuxiang, Wang, Xiaofang, Hemphill, Andrew, Matile, Hugues, Brun, Reto, Vennerstrom, Jonathan L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2007
Fag:
Mechanisms of Action: Physiological Effects
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1932508/
https://ncbi.nlm.nih.gov/pubmed/17562801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00225-07
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