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Expression of Allosteric Linkage between the Sodium Ion Binding Site and Exosite I of Thrombin during Prothrombin Activation
The specificity of thrombin for procoagulant and anticoagulant substrates is regulated allosterically by Na(+). Ordered cleavage of prothrombin (ProT) at Arg(320) by the prothrombinase complex generates proteolytically active, meizothrombin (MzT), followed by cleavage at Arg(271) to produce thrombin...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2292469/ https://ncbi.nlm.nih.gov/pubmed/17430903 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M610577200 |
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