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Novel Heparin Mimetics Reveal Cooperativity Between Exosite 2 and Sodium-Binding Site of Thrombin

INTRODUCTION: Thrombin is a primary target of most anticoagulants. Yet, thrombin’s dual and opposing role in pro- as well as anti- coagulant processes imposes considerable challenges in discovering finely tuned regulators that maintain homeostasis, rather than disproportionately changing the equilib...

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Bibliographische Detailangaben
Veröffentlicht in:Thromb Res
Hauptverfasser: Abdel Aziz, May H., Desai, Umesh R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5943173/
https://ncbi.nlm.nih.gov/pubmed/29573721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.thromres.2018.03.013
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