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The Role of Thrombin Exosites I and II in the Activation of Human Coagulation Factor V
Human blood coagulation Factor V (FV) is a plasma protein with little procoagulant activity. Limited proteolysis at Arg(709), Arg(1018), and Arg(1545) by thrombin or Factor Xa (FXa) results in the generation of activated FV, which serves as a cofactor of FXa in prothrombin activation. Both thrombin...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2292461/ https://ncbi.nlm.nih.gov/pubmed/17878169 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M701123200 |
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