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The Role of Thrombin Exosites I and II in the Activation of Human Coagulation Factor V

Human blood coagulation Factor V (FV) is a plasma protein with little procoagulant activity. Limited proteolysis at Arg(709), Arg(1018), and Arg(1545) by thrombin or Factor Xa (FXa) results in the generation of activated FV, which serves as a cofactor of FXa in prothrombin activation. Both thrombin...

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Main Authors: Segers, Kenneth, Dahlbäck, Björn, Bock, Paul E., Tans, Guido, Rosing, Jan, Nicolaes, Gerry A. F.
Formato: Artigo
Idioma:Inglês
Publicado: 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292461/
https://ncbi.nlm.nih.gov/pubmed/17878169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M701123200
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