The (1–63) Region of the p53 Transactivation Domain Aggregates In Vitro into Cytotoxic Amyloid Assemblies

The transcriptional regulator p53 plays an essential role in tumor suppression. Accordingly, it is found mutated, and its activity is reduced, in many human cancers. Recent reports show that some cancers are characterized by a loss of function of wild-type p53, which, in several cases, accumulates i...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Rigacci, Stefania, Bucciantini, Monica, Relini, Annalisa, Pesce, Alessandra, Gliozzi, Alessandra, Berti, Andrea, Stefani, Massimo
Format: Artigo
Langue:Inglês
Publié: The Biophysical Society 2008
Sujets:
Proteins
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292390/
https://ncbi.nlm.nih.gov/pubmed/18199664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.122283
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