Mild exposure of RIN-5F β-cells to human islet amyloid polypeptide aggregates upregulates antioxidant enzymes via NADPH oxidase-RAGE: An hormetic stimulus()

The presence of amyloid aggregates of human islet amyloid polypeptide (hIAPP), a hallmark of type 2 diabetes, contributes to pancreatic β-cell impairment, where oxidative stress plays a key role. A contribution of NADPH oxidase to reactive oxygen species (ROS) generation after cell exposure to micro...

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Bibliographische Detailangaben
Hauptverfasser: Borchi, Elisabetta, Bargelli, Valentina, Guidotti, Valentina, Berti, Andrea, Stefani, Massimo, Nediani, Chiara, Rigacci, Stefania
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2013
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887275/
https://ncbi.nlm.nih.gov/pubmed/24416718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2013.12.005
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