Mild exposure of RIN-5F β-cells to human islet amyloid polypeptide aggregates upregulates antioxidant enzymes via NADPH oxidase-RAGE: An hormetic stimulus()

The presence of amyloid aggregates of human islet amyloid polypeptide (hIAPP), a hallmark of type 2 diabetes, contributes to pancreatic β-cell impairment, where oxidative stress plays a key role. A contribution of NADPH oxidase to reactive oxygen species (ROS) generation after cell exposure to micro...

Full description

Saved in:
Bibliographic Details
Main Authors: Borchi, Elisabetta, Bargelli, Valentina, Guidotti, Valentina, Berti, Andrea, Stefani, Massimo, Nediani, Chiara, Rigacci, Stefania
Format: Artigo
Language:Inglês
Published: Elsevier 2013
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887275/
https://ncbi.nlm.nih.gov/pubmed/24416718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2013.12.005
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items