Treg Depletion Inhibits Efficacy of Cancer Immunotherapy: Implications for Clinical Trials

BACKGROUND: Regulatory T lymphocytes (Treg) infiltrate human glioblastoma (GBM); are involved in tumor progression and correlate with tumor grade. Transient elimination of Tregs using CD25 depleting antibodies (PC61) has been found to mediate GBM regression in preclinical models of brain tumors. Cli...

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Hlavní autoři: Curtin, James F., Candolfi, Marianela, Fakhouri, Tamer M., Liu, Chunyan, Alden, Anderson, Edwards, Matthew, Lowenstein, Pedro R., Castro, Maria G.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2008
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2291560/
https://ncbi.nlm.nih.gov/pubmed/18431473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001983
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