IL-27 gene therapy induces depletion of Tregs and enhances the efficacy of cancer immunotherapy

Tumor-induced expansion of Tregs is a significant obstacle to cancer immunotherapy. However, traditional approaches to deplete Tregs are often inefficient, provoking autoimmunity. We show here that administration of IL-27–expressing recombinant adeno-associated virus (AAV–IL-27) significantly inhibi...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:JCI Insight
Prif Awduron: Zhu, Jianmin, Liu, Jin-Qing, Shi, Min, Cheng, Xinhua, Ding, Miao, Zhang, Jianchao C., Davis, Jonathan P., Varikuti, Sanjay, Satoskar, Abhay R., Lu, Lanchun, Pan, Xueliang, Zheng, Pan, Liu, Yang, Bai, Xue-Feng
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2018
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5928864/
https://ncbi.nlm.nih.gov/pubmed/29618655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.98745
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