Intra-Tumoral Delivery of IL-27 Using Adeno-Associated Virus Stimulates Anti-tumor Immunity and Enhances the Efficacy of Immunotherapy

IL-27 is an anti-inflammatory cytokine that has been shown to have potent anti-tumor activity. We recently reported that systemic delivery of IL-27 using recombinant adeno-associated virus (rAAV) induced depletion of Tregs and significantly enhanced the efficacy of cancer immunotherapy in a variety...

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Bibliographic Details
Published in:Front Cell Dev Biol
Main Authors: Hu, Aiyan, Ding, Miao, Zhu, Jianmin, Liu, Jin-Qing, Pan, Xueliang, Ghoshal, Kalpana, Bai, Xue-Feng
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Cell and Developmental Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7118910/
https://ncbi.nlm.nih.gov/pubmed/32292786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.00210
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